The Diocese of Chikwawa covers the southern districts of Nsanje, Chikwawa, and parts of Thyolo and Blantyre, spanning 7,676 km². The Diocese is organized into 14 parishes grouped into four deaneries: Chikwawa, Nsanje, Molere, and Fatima. It was established as a suffragan see of the Archdiocese of Blantyre by Pope Paul VI on 22 March 1965. The patron saint of the Diocese is Our Lady, Cause of Our Joy (Causa Nostrae Letitiae).
The Diocese has been shepherded by three bishops. The first was Rt. Rev. Eugenius F.J. Vroemen, followed by Rt. Rev. Felix E. Mkhori (may their souls rest in peace). The current bishop, Rt. Rev. Peter Musikuwa, was appointed on 16 April 2003 and consecrated on 28 June 2003.